Microwave-assisted hydrothermal rapid synthesis of amorphous calcium phosphate nanoparticles and hydroxyapatite microspheres using cytidine 5鈥?triphosphate disodium salt as a phosphate source
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- 作者：Jing Zhao ; Ying-Jie Zhu ; y.j.zhu@mail.sic.ac.cn" class="auth_mail ; Guo-Feng Cheng ; Yin-Jie Ruan ; Tuan-Wei Sun ; Feng Chen ; Jin Wu ; Xin-Yu Zhao ; Guan-Jun Ding
- 关键词：Nanocrystalline materials ; Biomaterials ; Nanoparticles ; Microwave ; Hydroxyapatite
- 刊名：Materials Letters
- 出版年：1 June, 2014
- 年：2014
- 卷：124
- 期：Complete
- 页码：208-211
- 全文大小：1029 K
文摘
Calcium phosphates are important biomaterials for biomedical applications. Herein, we report microwave-assisted hydrothermal rapid synthesis of amorphous calcium phosphate (ACP) nanoparticles and hydroxyapatite (HAP) microspheres using cytidine 5鈥?triphosphate disodium salt as a phosphate source. This synthesis method does not need any surfactant and is very rapid (1 min at 150 掳C). The pH value has a significant effect on the morphology and crystallinity of the product. Aggregated ACP nanoparticles, hierarchically nanostructured solid HAP microspheres and hollow HAP microspheres are obtained at pH 7.0, 5.0 and 4.3, respectively. The as-prepared products are characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric (TG) analysis.