Selenium - containing mesoporous bioactive glass particles: Physicochemical and drug delivery properties

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• 作者：Xiang Wang^a ; Ying Zhang^a ; ^{yingzhang@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yiyi Ma^a ; Dongya Chen^a ; Huilin Yang^c ; Mingzhong Li^b ; ^{yingzhang@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Mesoporous bioactive glasses ; Selenium ; Doxorubicin delivery ; Malignant bone tumors
• 刊名：Ceramics International
• 出版年：2016
• 出版时间：1 February 2016
• 年：2016
• 卷：42
• 期：2
• 页码：3609-3617
• 全文大小：2798 K

文摘

Selenium (Se) incorporated mesoporous bioactive glasses (MBG) have been prepared using the traditional sol–gel method. The Se/MBG particles retain typical characteristics of mesoporous structures (S_BET=230–250 m²/g and D_P=4.0–4.1 nm) and excellent hydroxyapatite formation ability when soaked in simulated body fluids for 3 days. To investigate their delivery properties further, doxorubicin (DOX) was selected as a model drug. The results indicate that the Se/MBG particles exhibit sustained DOX delivery, and controlled release mechanism by Fickian diffusion according the Higuchi model. Based on a favorable in vitro bioactive response and controllable DOX delivery, this material is a promising candidate for application in malignant bone tumor therapy.