Contribution of the nitric oxide donor molsidomine and the antiparkinsonian drug l-DOPA to the modulation of the blood pressure in unilaterally 6-OHDA-lesioned rats
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- 关键词：BP ; blood pressure ; DA ; dopamine ; MFB ; medial forebrain bundle ; NO ; nitric oxide ; nNOS ; neuronal nitric oxide synthase ; 6-OHDA ; 6-hydroxydopamine ; OH ; orthostatic hypotension ; PD ; Parkinson&rsquo ; s disease ; SNc ; substantia nigra pars compacta ; STR ; striatum
- 刊名：Pharmacological Reports
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：69
- 期：1
- 页码：29-35
- 全文大小：652 K
- 卷排序：69
文摘
Molsidomine decreases BP in unilaterally 6-OHDA-lesioned rats 10 min after injection. Molsidomine jointly with l-DOPA evokes similar decrease in BP in 6-OHDA-lesioned rats. The molsidomine-mediated decline in BP was transient and disappeared after 24 h. In contrast to molsidomine antihypertensive drugs maintain long-term decline in BP. In PD molsidomine may decrease supine hypertension without worsening hypotension.