Improved Outcome of a Reduced Toxicity-Fludarabine, Cyclophosphamide, plus Antithymocyte Globulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia: Comparison of 2 Multicenter Prospective Studies
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- 作者：Hyoung Jin Kang1 ; &dagger ; ; Kyung Taek Hong1 ; &dagger ; ; Ji Won Lee1 ; Hyery Kim1 ; Kyung Duk Park1 ; Hee Young Shin1 ; Soo Hyun Lee2 ; Keon Hee Yoo2 ; Ki Woong Sung2 ; Hong Hoe Koo2 ; Jae Wook Lee3 ; Nak Gyun Chung3 ; Bin Cho3 ; Hack Ki Kim3 ; Kyung Nam Koh4 ; Ho Joon Im4 ; Jong Jin Seo4 ; Hyun Joo Jung5 ; Jun Eun Park5 ; Young Ho Lee6 ; Young Tak Lim7 ; Yeon Jung Lim8 ; Sun Young Kim8 ; Eun Sun Yoo9 ; Kyung Ha Ryu9 ; Jae Hee Lee10 ; Jeong-A Park11 ; Sang Kyu Park12 ; Hyo Seop Ahn1 ; hsahn@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; on behalf of The Korean Society of Pediatric Hematology-Oncology
- 关键词：Severe aplastic anemia ; Unrelated donor ; Fludarabine ; Cyclophosphamide ; Thymoglobulin ; Antithymocyte globulin (ATG)
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：22
- 期：8
- 页码：1455-1459
- 全文大小：383 K
文摘
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The optimal conditioning regimen for unrelated donor HSCT in SAA has not been defined.
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The 2 regimens using FLU, Cy, and ATG were compared.
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The regimen using a reduced dose of Cy and an increased dose of FLU showed better outcomes.
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A FLU, Cy, and ATG regimen with reduced toxicity could be optimal for unrelated donor HSCT in SAA.
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