Chronic intermittent hyperoxia alters the development of the hypoxic ventilatory response in neonatal rats
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- 作者：Sarah Logan1 ; Kristina E. Tobin ; Sarah C. Fallon ; Kevin S. Deng ; Amy B. McDonough ; Ryan W. Bavis ; rbavis@bates.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Developmental plasticity ; Control of breathing ; Carotid body ; Critical window ; Hyperoxia ; Hypoxia
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：220
- 期：Complete
- 页码：69-80
- 全文大小：1511 K
文摘
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Neonatal rats were reared in intermittent hyperoxia (30 or 60% O2, 5 bouts h−1).
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The hypoxic ventilatory response was blunted at P14-15 but recovered by adulthood.
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Chronic intermittent hyperoxia reduced carotid body size.
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This plasticity is not elicited when intermittent hyperoxia occurs later in life.