Cell type-specific roles of RAS-MAPK signaling in learning and memory: Implications in neurodevelopmental disorders
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- 作者：Hyun-Hee Ryua ; b ; Yong-Seok Leeb ; yongseok7@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CFC ; cardio-facio-cutaneous ; CS ; Costello syndrome ; FACS ; fluorescence-activated cell sorting ; GAPs ; GTPase activating proteins ; GEFs ; guanine nucleotide exchange factors ; GFP ; green fluorescent protein ; HCN ; hyperpolarization-activated cyclic nucleotide-gated channel ; iPSCs ; induced pluripotent stem cells ; LS ; Legius syndrome ; LTP ; long-term potentiation ; MAPK ; mitogen-activated protein kinase ; NF ; neurofibromin ; NMDA ; N-methyl-d-aspartate ; NS ; Noonan syndrome ; NSML ; Noonan syndrome with multip
- 刊名：Neurobiology of Learning and Memory
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：135
- 期：Complete
- 页码：13-21
- 全文大小：629 K
文摘
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RAS-MAPK signaling in different cell types plays distinct role in learning and LTP.
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Enhancing RAS signaling in inhibitory presynaptic neuron impairs learning and LTP.
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Enhancing RAS signaling in excitatory presynaptic neuron enhances learning and LTP.
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Enhancing RAS signaling in excitatory postsynaptic neuron impairs learning and LTP.