Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model
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- 作者：Hui Lu1 ; 4 ; 9 ; Ryan T. Ash2 ; 3 ; 9 ; Lingjie He1 ; 4 ; 8 ; Sara E. Kee2 ; Wei Wang1 ; 4 ; Dinghui Yu1 ; 6 ; Shuang Hao1 ; 6 ; Xiangling Meng1 ; 2 ; Kerstin Ure1 ; 4 ; Aya Ito-Ishida1 ; 4 ; Bin Tang1 ; 6 ; Yaling Sun1 ; 8 ; Daoyun Ji2 ; 7 ; Jianrong Tang1 ; 6 ; Benjamin R. Arenkiel1 ; 2 ; 4 ; Stelios M. Smirnakis2 ; 5 ; 10 ; Huda Y. Zoghbi1 ; 2 ; 4 ; 5 ; 6 ; 8 ; hzoghbi@bcm.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：17 August 2016
- 年：2016
- 卷：91
- 期：4
- 页码：739-747
- 全文大小：2550 K
文摘
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Shared CA1 circuit dysfunction in both MeCP2 loss- and gain-of-function models
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MeCP2 loss in excitatory and inhibitory neurons differently drives hypersynchrony
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Reduced excitatory synaptic response in oriens-layer interneurons upon loss/gain of MeCP2
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DBS rescues neural circuit dysfunction in hippocampal CA1 of Rett mice