High fat diet induced-obesity facilitates anxiety-like behaviors due to GABAergic impairment within the dorsomedial hypothalamus in rats
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- 作者：Sylvana Rendeiro de Noronha ; Glenda Viggiano Campos ; Aline Rezende Abreu ; Aline Arlindo de Souza ; Deoclé ; cio A. Chianca Jr. ; Rodrigo C. de Menezes ; rodrigo.menezes@iceb.ufop.br" class="auth_mail" title="E-mail the corresponding author ; rodrigorcam@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Obesity ; High-fat diet ; Anxiety ; Dorsomedial hypothalamus ; GABA
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：38-46
- 全文大小：1971 K
文摘
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HFD facilitates the development of anxiety-related behavior.
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Muscimol intra-dorsomedial hypothalamus has an anxiogenic effect in obese rats.
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BMI intra-dorsomedial hypothalamus does not cause an anxiogenic effect in obese rats.
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Memory acquisition and locomotor activity are not altered by GABAergic manipulation.