The inhibitory effect of beta-lapachone on RANKL-induced osteoclastogenesis

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• 作者：Dong Ryun Gu^a ; ^b ; Joon No Lee^b ; Gi-Su Oh^b ; Hyung Jin Kim^b ; Min Seuk Kim^c ; ^d ; Seoung Hoon Lee^a ; ^b ; ^d ; ^e ; ^{leesh2@wku.ac.kr}
• 关键词：Osteoclast ; β-Lapachone ; Osteoclastogenesis ; PPARγ ; PGC1β ; Osteoporosis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1073-1079
• 全文大小：2071 K
• 卷排序：482

文摘

β-lapachone (β-L) inhibits RANKL-mediated osteoclastogenesis. β-L increases the intracellular NAD+/NADH ratio, which is followed by activation of AMPK in osteoclasts. The activation of AMPK by β-L inhibits c-Fos and NFATc1 expression in RANKL-induced osteoclastogenesis. β-L also suppresses c-Fos and NFATc1 expression via downregulation of PPARγ and PGC1β expression.