Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells
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- 作者：Marisa M. Ferná ; ndeza ; 1 ; Fá ; tima Ferragutb ; 1 ; Ví ; ctor M. Cá ; rdenas Delgadob ; Candelaria Bracalenteb ; Alicia I. Bravoc ; Alejandro J. Cagnonid ; Myriam Nuñ ; eze ; Luciano G. Morosid ; f ; Hé ; ctor R. Quintab ; Marí ; a V. Espeltb ; Marí ; a F. Troncosob ; Carlota Wolfenstein-Todelb ; Karina V. Mariñ ; od ; Emilio L. Malchiodia ; Gabriel A. Rabinovichf ; g ; Marí ; a T. Elolab ; mt_elola@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：2AB ; 2-aminobenzamide ; ALCAM ; Activated leukocyte cell adhesion molecule ; ALCAMe ; Endogenous ALCAM from MDA-MB-231 cells ; ALCAMgly ; Recombinant glycosylated ALCAM expressed in HEK-293 cells ; ALCAMnongly ; Non-glycosylated ALCAM ; ADAM17 ; A disintegrin and metalloprotease 17 ; CM ; Conditioned medium ; CRD ; Carbohydrate recognition domain ; DABCO ; Diazabicyclo[2.2.2]octane ; DCIS ; Ductal carcinoma in situ ; EDTA ; Ethylene-diaminetetraacetic acid ; EEA1 ; Early endosomal antigen 1 ; ER ; Estrogen receptor ; FB
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：1860
- 期：10
- 页码：2255-2268
- 全文大小：2419 K
文摘
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Endogenous ALCAM from MDA-MB-231 breast cancer cells interacts with galectin-8.
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Exogenous galectin-8 provokes ALCAM segregation and clustering at the cell surface.
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ALCAM from MDA-MB-231 cells has high levels of α(2,6) sialylated glycans.
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Galectin-8 and ALCAM are co-expressed in normal and malignant human breast tissues.
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