Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury

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• 作者：Pavl&iacute ; na Ha&scaron ; ková ; ^a ; Hana Jansová ; ^a ; Jan Bure&scaron ; ^a ; Miloslav Machá ; ček^a ; Anna Jirkovská ; ^a ; Katherine J. Franz^b ; Petra Kovař&iacute ; ková ; ^a ; Tomá ; &scaron ; &Scaron ; imůnek^a ; ^{Tomas.Simunek@faf.cuni.cz}
• 关键词：ACN ; acetonitrile ; BHAPI ; (E)-Ń-(1-(2-((4-(4 ; 4 ; 5 ; 5-tetramethyl-1 ; 2 ; 3-dioxoborolan-2-yl)benzyl)oxy)phenyl)ethylidene) isonicotinohydrazide ; CA ; catecholamine ; CHEL ; iron chelator ; DCF ; 2&prime ; 7&prime ; -dichlorofluorescein ; DMSO ; dimethyl sulfoxide ; EC50 value ; concentration that reduces the toxicity induced by catecholamines to 50% of the viability of control cells (half-maximal effective concentration) ; EPI ; epinephrine ; FAC ; ferric ammonium citrate ; FAS ; ferrous ammonium sulphate ; FBS ; fetal b
• 刊名：Toxicology
• 出版年：2016
• 出版时间：14 September 2016
• 年：2016
• 卷：371
• 期：Complete
• 页码：17-28
• 全文大小：2355 K
• 卷排序：371

文摘

Fe prochelator BHAPI was examined for protection against catecholamine cardiotoxity. BHAPI has no affinity for iron ions until it is activated to active chelator HAPI. Catecholamines, as a source of ROS, induced conversion of BHAPI into HAPI. BHAPI and HAPI decrease ROS formation induced by catecholamines. BHAPI and HAPI protect H9c2 cells against oxidative injury induced by catecholamines.