Characteristics of silver nanoparticles in vehicles for biological applications

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• 作者：Kristina Kejlová ; ^a ; ^{kristina.kejlova@szu.cz" class="auth_mail" title="E-mail the corresponding author} ; Věra Ka&scaron ; pá ; rková ; ^b ; Daniel Krsek^a ; Dagmar J&iacute ; rová ; ^a ; Hana Kolá ; řová ; ^c ; Marké ; ta Dvořá ; ková ; ^a ; Kateřina Tomá ; nková ; ^c ; Veronika Mikulcová ; ^b
• 关键词：Silver nanoparticles ; Particle size and distribution ; Dynamic light scattering ; Transmission electron microscopy ; Phosphate buffered saline ; Culture medium
• 刊名：International Journal of Pharmaceutics
• 出版年：2015
• 出版时间：30 December 2015
• 年：2015
• 卷：496
• 期：2
• 页码：878-885
• 全文大小：2270 K

文摘

Silver nanoparticles (AgNPs) have been used for decades as anti-bacterial agents in various industrial fields such as cosmetics, health industry, food storage, textile coatings and environmental applications, although their toxicity is not fully recognized yet. Antimicrobial and catalytic activity of AgNPs depends on their size as well as structure, shape, size distribution, and physico-chemical environment. The unique properties of AgNPs require novel or modified toxicological methods for evaluation of their toxic potential combined with robust analytical methods for characterization of nanoparticles applied in relevant vehicles, e.g., culture medium with/without serum and phosphate buffered saline.