Neonatal exposure to a glyphosate based herbicide alters the development of the rat uterus

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• 作者：Marlise Guerrero Schimpf ; Marí ; a M. Milesi ; Paola I. Ingaramo ; Enrique H. Luque ; Jorgelina Varayoud ; ^{varayoud@fbcb.unl.edu.ar}
• 关键词：CK ; cytokeratin ; DES ; diethylstilbestrol ; EDCs ; endocrine-disrupting chemicals ; ERα ; estrogen receptor alpha ; GBHs ; glyphosate-based herbicides ; IARC ; International Agency for Research on Cancer ; IHC ; immuhistochemistry ; IOD ; integral optical density ; LEH ; luminal epithelial hyperplasia ; PND ; postnatal day ; PR ; progesterone receptor ; RfD ; reference dose ; U.S. EPA ; United StatesEnvironmental Protection Agency ; Vv ; Volume fraction
• 刊名：Toxicology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：376
• 期：Complete
• 页码：2-14
• 全文大小：7291 K
• 卷排序：376

文摘

Neonatal exposure to GBH lead to endometrial hyperplasia and increase proliferation. GBH disrupts proteins involved in uterine organogenetic differentiation. GBH exposure induced persistent increase of PR and Hoxa10 proteins.