Idebenone protects against oxidized low density lipoprotein induced mitochondrial dysfunction in vascular endothelial cells via GSK3尾/尾-catenin signalling pathways
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- 作者：Pengfei Lina ; c ; 1 ; Junling Liua ; b ; 1 ; Ming Renb ; Kunqian Jia ; Ling Lia ; Bin Zhanga ; Yaoqin Gongd ; Chuanzhu Yana ; c ; chuanzhuyan@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Idebenone ; oxLDL ; Apoptosis ; Mitochondria ; GSK3尾/尾-catenin signallingpathways
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：25 September 2015
- 年：2015
- 卷：465
- 期：3
- 页码：548-555
- 全文大小：1745 K
文摘
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Idebenone protected endothelial cells against oxLDL-induced apoptosis.
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Idebenone inhibited apoptosis induced by oxLDL through the mitochondrial-dependent apoptotic pathway.
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Idebenone protected against oxLDL-mediated cytotoxicity via GSK3尾/尾-catenin signalling pathways.
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Idebenone is a promising agent in the treatment or prevention of atherosclerosis.