Potential health risk of allergenic pollen with climate change associated spreading capacity: Ragweed and olive sensitization in two German federal states

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• 作者：Conny Hö ; flich^a ; ^{conny.hoeflich@uba.de" class="auth_mail" title="E-mail the corresponding author} ; Galina Balakirski^b ; Zuzanna Hajdu^c ; Jens Malte Baron^b ; Lorraine Kaiser^a ; Katharina Czaja^b ; Hans F. Merk^b ; Sarah Gerdsen^b ; Ulrich Strassen^c ; Murat Bas^c ; Henning Bier^c ; Wolfgang Dott^d ; Hans-Guido Mü ; cke^a ; Wolfgang Straff^a ; Adam Chaker^c ; ^e ; Stefani Rö ; seler^b
• 关键词：CO2 ; carbon dioxide ; NRW ; North Rhine-Westphalia ; IgE ; immunoglobulin E ; sIgE ; specific IgE ; DEGS1 ; first wave of the German Health and Interview Survey for Adults ; UBA ; German Federal Environment Agency ; GA2LEN ; Global Allergy and Asthma European Network ; SBE ; standardized biological units ; IR ; index of reactivity ; G/V ; weight/volume ; ISAC ; Immuno Solid-phase Allergen Chip ; ISU ; ISAC-standardized units ; n.a. ; not analyzed ; n/a ; not applicable ; PID ; German Pollen Information Service Foundation
• 刊名：International Journal of Hygiene and Environmental Health
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：219
• 期：3
• 页码：252-260
• 全文大小：640 K

文摘

Global climate changes may influence the geographical spread of allergenic plants thus causing new allergen challenges.

Objective

Allergy patients from two German federal states were compared for their status quo sensitization to ragweed, an establishing allergen, olive, a non-established allergen, and the native allergens birch, mugwort, and ash.

Methods

Between 2011 and 2013, 476 adult allergy patients per region were recruited. Patients completed a questionnaire, participated in a medical interview, and underwent skin prick testing and blood withdrawal for analysis of specific IgE to allergen components (ISAC technology). Data on regional pollen load from 2006 to 2011 were acquired from the German Pollen Information Service Foundation.

Results

Prick test reactivity to ragweed and ash, respectively, was lower in Bavaria than in NRW (ragweed: p = 0.001, aOR = 0.54; ash: p = 0.001, aOR = 0.59), whereas prick test reactivity to olive was higher (p = 0.000, aOR = 3.09). Prick test reactivity to birch and mugwort, respectively, did not significantly differ. 1% (1/127) of patients with prick test reactivity to ragweed showed sIgE to Amb a 1, and 65% (86/132) of olive-but-not-ash reactive patients showed sIgE to Ole e 1 (NRW: 67%, Bavaria: 65%; p = 0.823, OR = 0.91). Regional differences in sensitization pattern were neither explainable by cross-reactivity to pollen pan-allergens nor non-exposure variables nor by reported plant population or pollen data.

Conclusions

Spread of ragweed and particularly olive may result in prompt occurrence of allergic symptoms. Early identification of invasive allergens due to climate change does need time and spatial close meshed measurement of respective indicator allergens and sensitization pattern.