Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells

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• 作者：Zhongwei Cao¹ ; ² ; ^{zhc2007@med.cornell.edu} ; Joseph M. Scandura³ ; Giorgio G. Inghirami⁴ ; Koji Shido¹ ; Bi-Sen Ding¹ ; ² ; ^{bid2004@med.cornell.edu} ; Shahin Rafii¹ ; ⁵ ; ^{srafii@med.cornell.edu}
• 关键词：tumor endothelial cell ; vascular niche ; angiocrine factors ; tumor microenvironment ; cancer stem cells ; chemoresistance ; insulin growth factor-1 ; tumor aggressiveness ; ETS2 ; IGFBP7/angiomodullin
• 刊名：Cancer Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：110-126
• 全文大小：10880 K
• 卷排序：31

文摘

Tumor endothelial cells (TECs) express checkpoint IGFBP7 suppressing tumor cells IGF1 induction in TECs expands chemoresistant cancer stem cell-expressing IGF1R FGFR1 activation in TECs induces ETS2 pathway to upregulate IGF1 and suppress IGFBP7 FGF4 by priming FGFR1+ endothelial cells enables engraftment of chemoresistant CSCs