Protective potential of epigallocatechin-3-gallate against benign prostatic hyperplasia in metabolic syndrome rats
详细信息 查看全文
- 作者：Jinglou Chen ; Hongping Song ; jinglouchen@126.com" class="auth_mail" title="E-mail the corresponding author ; 245529621@qq.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BPH ; benign prostatic hyperplasia ; ELISA ; enzyme linked immunosorbent assay ; EGCG ; epigallocatechin-3-gallate ; GPx ; glutathione peroxidase ; HFD ; high-fat diet ; IGFs ; insulin-like growth factors ; IGFBP-3 ; IGF binding protein-3 ; IL-1β ; interleukin-1β ; LFD ; low-fat diet ; MDA ; malondialdehyde ; MS ; metabolic syndrome ; PPARs ; peroxisome proliferator activated receptors ; SOD ; superoxide dismutase ; TC ; total cholesterol ; TG ; triglyceride ; TNF-α ; tumor necrosis factor-α ; VEGF ; vascular endothelial growth
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：45
- 期：Complete
- 页码：315-320
- 全文大小：1857 K
文摘
- •
There is relevance between BPH and MS.
- •
IGF and PPAR family seem to stand at the crossroad between BPH and MS.
- •
EGCG attenuated the levels of glucose, TC and TG, as well as alleviated the disorders of prostate in rats model of BPH and MS.
- •
EGCG modulated the IGF axis and PPARs expression.