Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation
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- 作者：Charlotte Proudhon1 ; 7 ; Valentina Snetkova1 ; 7 ; Ramya Raviram1 ; 2 ; Camille Lobry1 ; 8 ; Sana Badri1 ; 2 ; 3 ; Tingting Jiang4 ; Bingtao Hao1 ; Thomas Trimarchi1 ; Yuval Kluger4 ; Iannis Aifantis1 ; Richard Bonneau2 ; 5 ; 6 ; Jane A. Skok1 ; jane.skok@med.nyu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：enhancer-sharing ; gene regulation ; Igk ; localized and long-range contacts ; nuclear architecture ; super-enhancer ; Tcrb ; transcription factor binding ; transcriptional output
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：7 June 2016
- 年：2016
- 卷：15
- 期：10
- 页码：2159-2169
- 全文大小：2603 K
文摘
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Synergistic contacts between the elements of a super-enhancer contribute to activity
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Igk enhancers play diverse roles in lymphocyte development
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The Igk enhancer, MiEκ, contributes to regulation of Tcrb recombination
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Enhancer sharing can involve active as well as inactive regulatory elements
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