Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions

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• 作者：Melissa A. Campaniello^a ; Chris Mavrangelos^a ; Samuel Eade^a ; ^b ; Andrea M. Harrington^a ; L. Ashley Blackshaw^c ; Stuart M. Brierley^a ; Scott D. Smid^b ; Patrick A. Hughes^a ; ^{patrick.hughes@adelaide.edu.au}
• 关键词：BKCa ; large conductance voltage dependent and Ca2+ modulated K+ ion channel ; DRG ; dorsal root ganglia ; IBD ; Inflammatory Bowel Disease ; IBS ; Irritable Bowel Syndrome ; GI ; gastrointestinal ; IL ; interleukin ; MLN ; mesenteric lymph node ; LPMC ; lamina propria mononuclear cell ; TC ; TCYTOTOXIC ; TH ; THELPER ; TNBS ; Tri-nitrobenzene sulphonic acid ; TRPA1 ; Transient Receptor Potential Ankyrin 1 ; PI3K ; phosphoionositide-3-kinase
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：319-332
• 全文大小：1932 K
• 卷排序：60

文摘

Acute colitis causes a persistent influx of adaptive immune cells in the colon. Adaptive immune responses dominate in re-activated colitis. Acute colitis chronically alters viscero-sensory neuro-immune pathways. Targeting specific pathways would benefit different stages of colitis.