Opsoclonus in a patient with increased titers of anti-GAD antibody provides proof for the conductance-based model of saccadic oscillations
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- 作者：Aasef G. Shaikha ; b ; aasefshaikh@gmail.com" class="auth_mail" title="E-mail the corresponding author ; George Wilmotc
- 关键词：Saccade ; Burst neuron ; Immune ; Cerebellum ; GABA ; Glutamate
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：362
- 期：Complete
- 页码：169-173
- 全文大小：532 K
文摘
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AntiGAD antibodies can cause prominent ocular motor deficits.
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We describe opsoclonus with downbeat nystagmus in a patient with antiGAD antibody.
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Paucity in GABA can cause downbeat nystagmus.
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Anti-GAD antibody can impair action of GAD reduce degradation of glutamate.
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Increased glutamate and hyperexcitability of burst neurons can cause opsoclonus.