Dietary myo-inositol modulates immunity through antioxidant activity and the Nrf2 and E2F4/cyclin signalling factors in the head kidney and spleen following infection of juvenile fish with Aeromonas hydrophila
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- 作者：Wei-Dan Jianga ; b ; c ; 1 ; Kai Hua ; e ; 1 ; Yang Liua ; b ; c ; Jun Jianga ; b ; c ; Pei Wua ; b ; c ; Juan Zhaoa ; Yong-An Zhangd ; Xiao-Qiu Zhoua ; b ; c ; zhouxq@sicau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; xqzhouqq@tom.com" class="auth_mail" title="E-mail the corresponding author ; Lin Fenga ; b ; c ; fenglin@sicau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Myo-inositol ; Immunity ; Antioxidant ; Nrf2 ; E2F4 ; Requirement
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：49
- 期：Complete
- 页码：374-386
- 全文大小：2275 K
文摘
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MI deficiency depressed the immunity in the head kidney and spleen of fish.
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MI deficiency caused oxidative damage and antioxidant disruption in the immune organs of fish.
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MI deficiency inhibited the proliferation signalling, E2F4, etc, in the immune organs of fish.
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MI excess also caused negative effects on the immunity and integrity of the immune organs.
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The head kidney is more sensitiveness to MI nutrition than the spleen of fish.
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