Aeromonas salmonicida type III secretion system-effectors-mediated immune suppression in rainbow trout (Oncorhynchus mykiss)

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• 作者：F.C. Origgi^a ; ^b ; ^{francesco.origgi@vetsuisse.unibe.ch} ; O. Benedicenti^c ; H. Segner^b ; U. Sattler^b ; T. Wahli^b ; J. Frey^a
• 关键词：A. salmonicida ; Fish ; Immunity ; Immune suppression ; T3SS ; Disease ; Furunculosis
• 刊名：Fish & Shellfish Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：334-345
• 全文大小：1391 K
• 卷排序：60

文摘

Type 3 secretion system of Aeromonas salmonicida is associated with immunosuppression in fish. The presence of a functional type 3 secretion system is associated with death in fish infected with Aeromonas salmonicida. Aeromonas salmonicida with a defective type 3 secretion system is not lethal but still causes immunosuppression. Infection with Aeromonas salmonicida “cured” (no T3SS and effector genes) is not lethal and causes no immunosuppression.