Intravenous immunoglobulin therapy is rarely effective as the initial treatment in West syndrome: A retrospective study of 70 patients
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- 作者：Ryuki Matsuuraa ; b ; matsuura.ryuki@pref.saitama.lg.jp" class="auth_mail" title="E-mail the corresponding author ; Shin-ichiro Hamanoa ; hamano.shinichiro@pref.saitama.lg.jp" class="auth_mail" title="E-mail the corresponding author ; Yuko Hirataa ; b ; hirahira.yuko.0621@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Atsuko Obaa ; b ; sisotti@nifty.com" class="auth_mail" title="E-mail the corresponding author ; Kotoko Suzukia ; b ; kotoko.s@jikei.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kenjiro Kikuchia ; b ; kenjiro-k@jikei.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACTH ; Adrenocorticotrophic hormone ; DQ ; Developmental quotient ; EEG ; Electroencephalographic ; IQ ; Intelligence quotient ; IVIG ; Intravenous immunoglobulins ; SD ; Standard deviation
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：368
- 期：Complete
- 页码：140-144
- 全文大小：224 K
文摘
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This is the first study of Intravenous immunoglobulins (IVIG) therapy on a large number of patients with West syndrome.
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IVIG therapy is rarely effective as the initial treatment in West syndrome.
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The efficacy of IVIG therapy in our study was lower than that in previous studies.
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IVIG therapy has a good safety profile and we would recommend it for West syndrome cases with drug resistance, severe complications associated with profound brain damage, severe brain atrophy, and in immunocompromised patients.
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Patients with short treatment lag showed better seizure outcomes in IVIG therapy.