Region-specific increases in FosB/ΔFosB immunoreactivity in the rat brain in response to chronic sleep restriction

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• 作者：Shannon Hall^a ; Samü ; el Deurveilher^a ; Kristin Robin Ko^b ; Joan Burns^a ; Kazue Semba^a ; ^c ; ^d ; ^semba@dal.ca
• 关键词：ABC ; avidin-biotin-horseradish peroxidase complex ; ANOVA ; analysis of variance ; CSR ; chronic sleep restriction ; EC ; exercise control ; GABA ; γ-aminobutyric acid ; HC ; home cage ; ir ; immunoreactive ; LW ; locked wheel ; MCH ; melanin-concentrating hormone ; NREM ; non-rapid eye movement ; REC ; recovery ; REM ; rapid eye movement ; SEM ; standard error of the mean ; SR ; sleep restricted
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：30 March 2017
• 年：2017
• 卷：322
• 期：part_PA
• 页码：9-17
• 全文大小：1564 K
• 卷排序：322

文摘

Rats were partially sleep-deprived for 99 h using motorized wheels (3 h on/1 h off). FosB/ΔFosB immunohistochemistry was used as a marker of chronic neuronal activation. FosB/ΔFosB was induced in several sleep/wake, autonomic, and limbic brain regions. After 6 days of recovery from sleep restriction, FosB/ΔFosB was at control levels. FosB/ΔFosB may play a role in the allostatic responses to chronic sleep restriction.