Postnatal maturation of mouse medullo-spinal cerebrospinal fluid-contacting neurons

详细信息    查看全文

• 作者：Adeline Orts-Del&rsquo ; Immagine^a ; ^&Dagger ; ; Jé ; rô ; me Trouslard^a ; Coraline Airault^a ; Jean-Philippe Hugnot^b ; Baptiste Cordier^c ; Thierry Doan^c ; Anne Kastner^a ; ^&dagger ; ; Nicolas Wanaverbecq^a ; ^&dagger ; ; ^{nicolas.wanaverbecq@univ-amu.fr}
• 关键词：cc ; central canal ; cMe. ; caudal medulla ; CSF ; cerebrospinal fluid ; CSF-cN ; cerebrospinal fluid-contacting neuron ; DCX ; doublecortin ; DF ; degree of freedom ; DG ; dentate gyrus ; DVC ; dorsal vagal complex ; IQR ; interquartile distance ; IR ; immunoreactivity ; MAP-2 ; Microtubule-Associated Protein 2 ; Me. ; medulla oblongata ; NeuN ; neuronal nuclei protein ; OB ; olfactory bulb ; PC ; pericanal ; Phospho-CREB ; Phospho-cAMP Response Element-binding Protein ; PKD2L1 ; polycystin kidney disease 2-like 1 protein ; PSA
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：39-54
• 全文大小：3997 K
• 卷排序：343

文摘

We examined maturation and morphology changes in PKD2L1+ medullo-spinal CSF-cNs in mice. With aging CSF-cNs density decreased and intra-ependymal neurons were only found in p0 mice. CSF-cNs in newborn mice expressed doublecortin, PSA-NCAM and phospho-CREB but not TUC4. CSF-cNs in adults had a low expression level for NeuN but still express immaturity markers. Altogether, it appears the CSF-cNs present a peculiar phenotype with a low maturation state.