Targeted Therapy and Immunosuppression in the Tumor Microenvironment

详细信息    查看全文

• 作者：Michael J. Allegrezza¹ ; Jose R. Conejo-Garcia¹ ; ^{jrconejo@Wistar.org}
• 关键词：targeted therapies ; tumor microenvironment ; cancer immunotherapy ; small-molecule inhibitors
• 刊名：Trends in Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：3
• 期：1
• 页码：19-27
• 全文大小：1389 K
• 卷排序：3

文摘

Small-molecule inhibitors offer great promise for targeting pathways that are specifically deregulated in different tumors. However, such ‘targeted’ therapies also elicit poorly understood effects on protective antitumor immunity. Given the emerging relevance of immunotherapies that boost pre-existing T cell responses, understanding how different immune cells are affected by small-molecule inhibitors could lead to more-effective interventions, alone or combined with immunotherapy. This review discusses the growing array of activities elicited by multiple ‘targeted’ inhibitors on antitumor immunity, underscoring the complex effects resulting from diverse activities on different immune cell types in vivo, and the need to conduct mechanistic research that identifies drugs performing well not only in immunocompromised mice but also in the presence of spontaneous or therapeutic antitumor immunity.