Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy

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• 作者：Peter M. Grace<sup>asup><sup> ; sup><sup>1sup><sup> ; sup><sup>peter.grace@colorado.edusup> ; Lisa C. Loram<sup>asup><sup> ; sup><sup>1sup> ; John P. Christianson<sup>asup> ; Keith A. Strand<sup>asup> ; Johanna G. Flyer-Adams<sup>asup> ; Kathryn R. Penzkover<sup>bsup> ; John R. Forsayeth<sup>csup> ; Anne-Marie van Dam<sup>dsup> ; Melissa J. Mahoney<sup>bsup> ; Steven F. Maier<sup>asup> ; Raymond A. Chavez<sup>csup> ; Linda R. Watkins<sup>asup><sup> ; sup><sup>csup>
• 关键词：EAE ; experimental autoimmune encephalomyelitis ; IL-10 ; interleukin 10 ; IFA ; incomplete Freund&rsquo ; s adjuvant ; MS ; multiple sclerosis ; MOG ; myelin oligodendrocyte glycoprotein
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：49-54
• 全文大小：1079 K
• 卷排序：59

文摘

Rat EAE was associated with neuropathic pain, anxiety and fatigue. These symptoms were attenuated by a novel IL-10 gene therapy formulation. Depressed wheel running preceded motor deficit, and may predict symptom onset.