Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics
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- 作者：Sergio Anastasia ; anastasi@ifo.it" class="auth_mail" title="E-mail the corresponding author ; Dante Lambertia ; lamberti@ifo.it" class="auth_mail" title="E-mail the corresponding author ; Stefano Alemà ; b ; alema@ibc.cnr.it" class="auth_mail" title="E-mail the corresponding author ; Oreste Segattoa ; segatto@ifo.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：RTK ; receptor tyrosine kinase ; EGF ; epidermal growh factor ; EGFR ; epidermal growth factor receptor ; LRIG1 ; leucin-rich repeats and immunoglobulin-like domains1 ; MIG ; 6mitogen inducible gene 6 ; RALT ; receptor associated late transducer ; ERRFI1 ; ErbB receptor feedback inhibitor 1 ; SOCS ; suppressor of cytokine signaling ; EBR ; ErbB binding region ; TKD ; tyrosine kinase domain ; ARF ; ADP-ribosylation factor ; RED ; RALT endocytic domain ; CBL ; casitas B-lineage lymphoma ; HGF ; hepatocyte growth factor ; PDG
- 刊名：Seminars in Cell & Developmental Biology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：50
- 期：Complete
- 页码：115-124
- 全文大小：1401 K
文摘
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MIG6 plays a necessary role of in negative feedback regulation of ErbB receptors.
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MIG6 suppresses EGFR signaling via kinase inhibition and down-regulation.
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MIG6 loss enhances oncogenic ErbB signaling.
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MIG6 loss in tumors is a potential biomarker of oncogenic addiction to ErbB signaling.
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