A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

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• 作者：Mara Biasin^a ; ¹ ; ^{mara.biasin@unimi.it} ; Manuela Sironi^b ; ¹ ; Irma Saulle^a ; Chiara Pontremoli^b ; Micaela Garziano^a ; Rachele Cagliani^b ; Daria Trabattoni^a ; Sergio Lo Caputo^c ; Francesca Vichi^c ; Francesco Mazzotta^c ; Diego Forni^b ; Stefania Riva^b ; Wbeimar Aguilar-Jimenez^d ; Samandhy Cedeñ ; o^f ; ^g ; ^h ; Jorge Sanchezⁱ ; Christian Brander^f ; ^g ; ^h ; Wildeman Zapata^d ; ^e ; Maria Teresa Rugeles^d ; Mario Clerici^j
• 关键词：HIV ; HESN ; TIM-1 ; Polymorphism ; Resistance to infection
• 刊名：Microbes and Infection
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：19
• 期：1
• 页码：69-74
• 全文大小：276 K
• 卷排序：19

文摘

We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.