G-CSF treatment promotes apoptosis of autoreactive T cells to restrict the inflammatory cascade and accelerate recovery in experimental allergic encephalomyelitis

详细信息    查看全文

• 作者：Wei Peng ; ^{pengwei39@hotmail.com}
• 关键词：Granulocyte colony-stimulating factor ; Autoreactive T cells ; Apoptosis ; Experimental allergic encephalomyelitis
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：289
• 期：Complete
• 页码：73-84
• 全文大小：1652 K
• 卷排序：289

文摘

G-CSF inhibits inflammatory infiltration and demyelination in CNS of EAE mice. G-CSF prevents pro-inflammatory cytokine and NO productions, and increases IL-4 and IL-10 secretions. G-CSF suppresses autoreactive T cell proliferation through apoptosis. G-CSF induces resting G0/G1-phase into S-phase of autoreactive T cells to promote anti-inflammatory action. G-CSF elevates a CD4+ CD25+ T cell subset that displays potent neuroprotective effects.