Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds
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- 作者：Rebeca Santes-Palaciosa ; Antonio Romo-Mancillasb ; Rafael Camacho-Carranzaa ; Jesú ; s Javier Espinosa-Aguirrea ; jjea99@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ER ; 7-ethoxyresorufin ; NAR ; naringenin ; DHB ; 6&prime ; 7&prime ; -dihydroxybergamottin
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：258
- 期：Complete
- 页码：267-275
- 全文大小：1566 K
文摘
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Interspecies differences on inhibition of CYP1A1 were found.
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Rat CYP1A1enzyme is more sensible to inhibition than human CYP1A1.
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Naringenin showed different mechanism of inhibition of CYP1A1.
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Molecular modeling suggested differences in interactions of inhibitors with CYP1A1.