PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity

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• 作者：Xin Luo¹ ; ² ; ³ ; ⁸ ; Keun Woo Ryu¹ ; ² ; ³ ; ⁸ ; Dae-Seok Kim¹ ; ² ; Tulip Nandu¹ ; ² ; Carlos J. Medina⁴ ; Rebecca Gupte¹ ; ² ; Bryan A. Gibson¹ ; ² ; ⁵ ; Raymond E. Soccio⁴ ; Yonghao Yu⁶ ; Rana K. Gupta⁷ ; W. Lee Kraus¹ ; ² ; ³ ; ⁹ ; ^{lee.kraus@utsouthwestern.edu}
• 关键词：adipogenesis ; C/EBPβ ; DNA binding ; gene expression ; PARP inhibitor ; PARP-1 ; PARylation ; poly(ADP-ribose) ; transcription
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：65
• 期：2
• 页码：260-271
• 全文大小：2650 K
• 卷排序：65

文摘

Inhibition or depletion of PARP-1 promotes the adipogenic differentiation program PARP-1 PARylates C/EBPβ on three residues in a conserved regulatory domain PARylation of C/EBPβ inhibits DNA binding, transcriptional activity, and adipogenesis Mutation of the C/EBPβ PARylation sites produces a superactive transcription factor