Increased circulating procoagulant and anticoagulant factors as TF and TFPI according to severity or infecting serotypes in human dengue infection

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• 作者：Elzinandes Leal de Azeredo^a ; ^{elzinandes@ioc.fiocruz.br} ; Victor Edgar Fiestas Soló ; rzano^a ; Dé ; bora Batista de Oliveira^a ; Cintia Ferreira Marinho^a ; Luiz José ; de Souza^b ; Rivaldo Venâ ; ncio da Cunha^c ; Paulo Vieira Damasco^d ; ^e ; Claire Fernandes Kubelka^a ; Luzia Maria de-Oliveira-Pinto^a
• 关键词：TFPI ; TF ; Dengue
• 刊名：Microbes and Infection
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：19
• 期：1
• 页码：62-68
• 全文大小：297 K
• 卷排序：19

文摘

Tissue Factor (TF) is the initiator of coagulation and Tissue Factor Inhibitor (TFPI) is the physiological inhibitor of the TF/FVIIa complex. Circulating levels of TF and TFPI were quantified in dengue patients and the relationships with disease severity and infecting serotype analysed. A significant decrease in TF and TPFI plasma levels was observed in mild DF patients compared with severe dengue. Furthermore, both factors were associated with haemorrhagic manifestations. Finally, TF levels were significantly increased in DENV-1/2 infected patients as compared with DENV-4. These findings suggest that activation of TF-pathway is an important component of DENV -related coagulation disorders.