Atypical IκB proteins in immune cell differentiation and function
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- 作者：Michaela Annemanna ; Carlos Plaza-Sirventa ; b ; Marc Schustera ; b ; 1 ; Konstantinos Katsoulis-Dimitrioua ; b ; Stefanie Klichea ; Burkhart Schravena ; c ; Ingo Schmitza ; b ; ingo.schmitz@helmholtz-hzi.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARD ; ankyrin repeat domain ; ANK ; ankyrin repeats ; Bcl-3 ; B cell lymphoma 3 protein ; EAE ; experimental autoimmune encephalomyelitis ; ERK ; extracellular-signal-regulated kinase ; FO ; follicular ; GC ; germinal centre ; IκB ; inhibitor of NF-κB ; NF-κB ; nuclear factor kappa-light-chain-enhancer of activated B cells ; LPS ; lipopolysaccharide ; MZ ; marginal zone ; PP ; Peyeŕs Patches ; RHD ; Rel homology domain ; TAD ; transcription activation domain ; TCR ; T cell receptor ; TLR ; toll like receptor
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：171
- 期：Complete
- 页码：26-35
- 全文大小：1285 K
文摘
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NF-κB is regulated by IκB proteins.
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The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins.
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Nuclear IκB proteins regulate differentiation, maturation and activation of immune cells.
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Nuclear IκB proteins are promising targets for the development of new therapies of autoimmunity and infectious diseases
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