Direct injection LC-MS/MS method for the determination of teicoplanin in human plasma
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- 作者：Kwang-Youl Kima ; 1 ; Sang-Heon Choa ; 1 ; Yong-Hyun Songa ; Moon-Suk Nama ; b ; Cheol-Woo Kima ; b ; cwkim1805@inha.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Teicoplanin ; Multiple reaction monitoring ; Direct injection ; Therapeutic drug monitoring
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：1008
- 期：Complete
- 页码：125-131
- 全文大小：1289 K
文摘
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We developed a direct injection-based LC–MS/MS method to obtain teicoplanin in human plasma.
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Only 20 μL of plasma was required for sample preparation.
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Patient plasma samples were diluted in an aqueous buffer prior to injection into the LC–MS/MS system.
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The method was fully validated and successfully applied to therapeutic drug monitoring (TDM) of teicoplanin in routine clinical practice.