STAT4 knockout protects LPS-induced lung injury by increasing of MDSC and promoting of macrophage differentiation
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- 作者：Cuiping Fua ; 1 ; Liyan Jiangb ; 1 ; Xiaobo Xua ; Fen Zhua ; Shuqi Zhanga ; Xu Wua ; Zilong Liua ; Xiangdong Yangc ; yang.xiangdong@zs-hospital.sh.cn" class="auth_mail" title="E-mail the corresponding author ; Shanqun Lia ; li.shanqun@zs-hospital.sh.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lung injury ; STAT4 ; MDSCs ; Macrophages
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：223
- 期：Complete
- 页码：16-22
- 全文大小：2806 K
文摘
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STAT4 knockout(KO) decreases the lethality after lipopolysaccharide instillation.
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STAT4 KO ameliorates lipopolysaccharide-induced lung injury.
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CD11b+Gr-1+ myeloid cells increased in blood of STAT4 KO mice.
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Macrophages increased and neutrophils decreased in lung of STAT4 KO mice.
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M1-like cytokines reduced while M2-like cytokine increased in STAT4 KO mice.