Apolipoprotein E polymorphisms in frontotemporal lobar degeneration: A meta-analysis

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• 作者：Elisa Rubino ; Aless ; ro Vacca ; Flora Govone ; Paola De Martino ; Lorenzo Pinessi ; Innocenzo Rainero
• 关键词：Frontotemporal lobar degeneration ; Case&ndash ; control study ; APOE ; Polymorphism ; Meta-analysis
• 刊名：Alzheimer's Dementia
• 出版年：November, 2013
• 年：2013
• 卷：9
• 期：6
• 页码：706-713
• 全文大小：707 K

文摘

Objective

Case-control studies have not been consistent in showing association between apolipoprotein E (APOE) polymorphisms and frontotemporal lobar degeneration (FTLD), producing contradictory findings. The study objective was to define and quantify further the disease risk associated with the carriage of different APOE alleles to determine whether APOE gene polymorphism is a risk factor for FTLD.

Methods

A systematic review of all case-control studies investigating the association between the APOE gene and FTLD up to December 2011 was conducted. Case-control studies using clinical or pathological criteria for FTLD and reporting APOE allelic or genotypic data were included. Pooled odds ratios (ORs) were estimated using a random effects model, and 95% confidence intervals (CIs) were calculated.

Results

Twenty-eight case-control studies met the inclusion criteria. Carriage of the 蔚2 allele had no effect on disease risk. On the contrary, carriage of the 蔚4 allele was associated with a significantly increased disease risk (蔚4 carriers vs non-蔚4 carriers: OR, 1.94; 95% CI, 1.43-2.64; 蔚4 vs 蔚3 allele:聽OR, 1.83; 95% CI, 1.34-2.52). Furthermore, a gene-dosage effect for the 蔚4 allele was found. There was no evidence of publication bias, but heterogeneity between the studies was high.

Conclusions

Our study provides evidence for an association between the APOE 蔚4 allele and frontotemporal lobar degeneration.