An efficient room temperature preparation of bromo difluorovinylzinc reagent (CF2
CBrZnCl) and a high yield one-pot synthesis of α-
CBrZnCl) and a high yield one-pot synthesis of α-
详细信息 查看全文
- 作者：Anilkumar ; R. ; Burton ; Donald J.
- 关键词：2-Bromo-1 ; 1 ; 1-trifluoroethane ; 2-Bromo-1 ; 1-difluoroethylene ; Bromodifluorovinylzinc ; Pd(0) coupling ; Bromodifluorovinyllithium ; α ; -Bromo-β ; β ; -difluorostyrene
- 刊名：Journal of Fluorine Chemistry
- 出版年：2004
- 出版时间：April, 2004
- 年：2004
- 卷：125
- 期：4
- 页码：561-566
- 全文大小：128 K
文摘
A high yield room temperature preparation of the1-bromo-2,2-difluorovinylzinc reagent [CF2CBrZnCl] (>89 % ) was achieved via insitu metallation of CF3CH2Br or CF2CHBr with LDA in presence of ZnCl2. Palladium catalyzed cross-coupling of this zinc reagent with aryl iodides provides α-bromo-β,β-trifluorostyrenes (ArCBrCF2) in 64–86 % isolated yields, in an essentially ‘one-pot’ procedure.
CBrZnCl] (>89 % ) was achieved via insitu metallation of CF3CH2Br or CF2CHBr with LDA in presence of ZnCl2. Palladium catalyzed cross-coupling of this zinc reagent with aryl iodides provides α-bromo-β,β-trifluorostyrenes (ArCBrCF2) in 64–86 % isolated yields, in an essentially ‘one-pot’ procedure.