National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report

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• 作者：Saro H. Armenian¹ ; ^{sarmenian@coh.org} ; Wassim Chemaitilly² ; Marcus Chen³ ; Eric J. Chow⁴ ; Christine N. Duncan⁵ ; Lee W. Jones⁶ ; Michael A. Pulsipher⁷ ; Alan T. Remaley³ ; Alicia Rovo⁸ ; Nina Salooja⁹ ; Minoo Battiwalla¹⁰
• 关键词：National Institutes of Health consensus ; Late effects ; Hematopoietic cell transplantation ; Cardiovascular disease ; Cardiovascular risk factors ; Chronic disease ; Survivorship
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：23
• 期：2
• 页码：201-210
• 全文大小：486 K
• 卷排序：23

文摘

A number of studies have shown that autologous and allogeneic hematopoietic cell transplantation (HCT) contribute to an increased incidence of cardiovascular disease (CVD) and worsening of cardiovascular risk factors that could contribute to further CVD over time. These observations, combined with a notable increase in the number of survivors after HCT in recent years, highlight the need for studies aimed at modifying risk or preventing these outcomes by changing specific approaches and/or post-HCT interventions. To address these issues, the National Heart, Lung and Blood Institute and National Cancer Institute co-sponsored an international initiative on late effects after HCT. This report summarizes the major gaps in knowledge along with detailed recommendations regarding study priorities from the Cardiovascular Disease and Associated Risk Factors Committee, a multidisciplinary panel of international experts. The committee calls for specific studies aimed at understanding and preventing arterial disease and cardiac dysfunction (heart failure, valvular disease, and arrhythmias), as well as decreasing cardiovascular risk factors (hypertension, hyperglycemia, dyslipidemia, and sarcopenic obesity) after HCT.