Intentional Laceration of the Anterior Mitral Valve Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Replacement: Pre-Clinical Findings

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• 作者：Jaffar M. Khan ; BM BCh^a ; Toby Rogers ; BM BCh^a ; William H. Schenke ; BS^a ; Jonathan R. Mazal ; MS^a ; Anthony Z. Faranesh ; PhD^a ; Adam B. Greenbaum ; MD^b ; Vasilis C. Babaliaros ; MD^c ; Marcus Y. Chen ; MD^a ; Robert J. Lederman ; MD^a ; ^{lederman@nih.gov" class="auth_mail" title="E-mail the corresponding author}
• 关键词：left ventricular outflow tract obstruction ; mitral valve ; structural heart disease ; subvalvular aortic stenosis ; transcatheter mitral valve replacement ; valvular heart disease
• 刊名：JACC: Cardiovascular Interventions
• 出版年：2016
• 出版时间：12 September 2016
• 年：2016
• 卷：9
• 期：17
• 页码：1835-1843
• 全文大小：1910 K

文摘

The authors propose a novel transcatheter transection of the anterior mitral leaflet to prevent iatrogenic left ventricular outflow tract (LVOT) obstruction during transcatheter mitral valve replacement (TMVR).

Background

LVOT obstruction is a life-threatening complication of TMVR caused by septal displacement of the anterior mitral leaflet.

Methods

In vivo procedures in swine were guided by biplane x-ray fluoroscopy and intracardiac echocardiography. Retrograde transaortic 6-F guiding catheters straddled the anterior mitral leaflet. A stiff 0.014-inch guidewire with polymer jacket insulation was electrified and advanced from the LVOT, through the A2 leaflet base, into the left atrium. The wire was snared and externalized, forming a loop that was energized and withdrawn to lacerate the anterior mitral leaflet.

Results

The anterior mitral leaflet was successfully lacerated in 7 live and 1 post-mortem swine under heparinization. Lacerations extended to 89 ± 19% of leaflet length and were located within 0.5 ± 0.4 mm of leaflet centerline. The chordae were preserved and retracted the leaflet halves away from the LVOT. LVOT narrowing after benchtop TMVR was significantly reduced with intentional laceration of the anterior mitral leaflet to prevent LVOT obstruction than without (65 ± 10% vs. 31 ± 18% of pre-implantation diameter, p < 0.01). The technique caused mean blood pressure to fall (from 54 ± 6 mm Hg to 30 ± 4 mm Hg, p < 0.01), but blood pressure remained steady until planned euthanasia. No collateral tissue injury was identified on necropsy.

Conclusions

Using simple catheter techniques, the anterior mitral valve leaflet was transected. Cautiously applied in patients, this strategy can prevent anterior mitral leaflet displacement and LVOT obstruction caused by TMVR.