Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice
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- 作者：Jin Hwan Leea ; c ; Zheng Z Weia ; c ; Wenyuan Caoa ; Soonmi Wona ; Xiaohuan Gua ; c ; Megan Wintera ; Thomas A. Dixd ; e ; Ling Weia ; b ; Shan Ping Yua ; c ; spyu@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; BBB ; blood-brain barrier ; CCA ; common carotid artery ; Iba1 ; ionized calcium binding adaptor molecule 1 ; IFNγ ; interferon gamma ; IL-1β ; interleukin-1β ; IL-6 ; interleukin-6 ; IL-10 ; interleukin-10 ; IL-12 ; interleukin-12 ; IL-23 ; interleukin-23 ; iNOS ; inducible nitric oxide synthase ; IOS ; intrinsic optical signals ; IP-10 ; interferon-inducible protein ; MCP-1 ; monocyte chemoattractant protein-1 ; MIP-1α ; macrophage inflammatory protein-1α ; NT ; neurotensin ; NTR1 ; neurotensin
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：248-260
- 全文大小：1834 K
文摘
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Pharmacological and physical TH treatments are protective against ischemic stroke.
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10">TH reduces the expression of inflammatory factors.
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TH regulates microglial M1/M2 polarization and migration.
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TH improves functional recovery after stroke.
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The anti-inflammatory effect of TH is a brain protective mechanism after stroke.