Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses
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- 作者：Srirupa Chatterjee1 ; Christopher F. Basler2 ; cbasler@gsu.edu" class="auth_mail" title="E-mail the corresponding author ; Gaya K. Amarasinghe1 ; gamarasinghe@path.wustl.edu" class="auth_mail" title="E-mail the corresponding author ; Daisy W. Leung1 ; dleung@path.wustl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARM ; armadillo ; ATPase ; adenylpyrophosphatase ; BPA/B/C ; β-propeller A/B/C ; CRISPR ; clustered regularly interspaced short palindromic repeats ; mRNA ; messenger RNA ; dsRNA ; double-stranded RNA ; DDB1 ; damage-specific DNA-binding protein 1 ; EBOV ; Ebola virus ; G/GP ; glycoprotein ; IFIT ; IFN-induced proteins with tetratricopeptide repeat ; IFN ; interferon ; IFNAR ; IFNα/β receptor ; IID ; IFN inhibitory domain ; IKKε ; inhibitor of nuclear factor kappa-B kinase subunit ε ; IRF ; IFN regulatory factor ; ISG ; IFN-s
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：28 August 2016
- 年：2016
- 卷：428
- 期：17
- 页码：3467-3482
- 全文大小：2121 K
文摘
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Type I interferons are important for host innate immune responses.
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10">Non-segmented negative-sense RNA viruses are important human pathogens.
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15">Recent studies are uncovering key host–virus interactions in immune evasion.
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20">These studies provide novel targets for development of countermeasures.