Interleukin-1¦Â (IL-1¦Â) increases pain behavior and the blood glucose level: Possible involvement of glucocorticoid system
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- 作者：Yun-Beom Sim ; Soo-Hyun Park ; Yu-Jung Kang ; Jun-Sub Jung ; Ohk-Hyun Ryu ; Moon-Gi Choi ; Seong-Soo Choi ; Hong-Won Suh
- 关键词：IL-1¦Â ; interleukin-1¦Â ; CRH ; corticotrophin releasing hormone ; IT ; intrathecal ; IP ; intraperitoneal
- 刊名：Cytokine
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：64
- 期：1
- 页码：351-356
- 全文大小：408 K
文摘
The possible involvement of glucocorticoid system in interleukin-1¦Â (IL-1¦Â)-induced nociception and the blood glucose level was studied in ICR mice. In the first experiment, mice were treated intrathecally (i.t.) with IL-1¦Â (100 pg). Corticotrophin releasing hormone (CRH) mRNA (hypothalamus) and c-Fos mRNA (pituitary gland, spinal cord, and the adrenal gland) levels were measured at 30, 60 and 120 min after IL-1¦Â administration. We found that i.t. injection with IL-1¦Â increased CRH mRNA level in the hypothalamus. The IL-1¦Â administered i.t. elevated c-Fos mRNA levels in the spinal cord, pituitary and adrenal glands. Furthermore, i.t. administration of IL-1¦Â significantly increased the plasma corticosterone level up to 60 min. In addition, the adrenalectomy caused the reductions of the blood glucose level and pain behavior induced by IL-1¦Â injected i.t. in normal and D-glucose-fed groups. Furthermore, intraperitoneal (i.p.) pretreatment with RU486 (100 mg/kg) attenuated the blood glucose level and pain behavior induced by IL-1¦Â administered i.t. in normal and D-glucose-fed groups. Our results suggest that IL-1¦Â administered i.t. increases the blood glucose level and pain behavior via an activation of the glucocorticoid system.