Chronic intermittent ethanol induced axon and myelin degeneration is attenuated by calpain inhibition
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- 作者：Supriti Samantaraya ; samanta@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Varduhi H. Knaryana ; vknaryan@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Kaushal S. Patela ; kspatel1990@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Patrick J. Mulhollandb ; c ; mulholl@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Howard C. Beckerb ; c ; d ; beckerh@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Naren L. Banika ; d ; baniknl@musc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：A.U. ; arbitrary units ; CIE ; chronic intermittent ethanol ; CNPase ; 2&prime ; 3&prime ; -cyclic nucleotide 3&prime ; -phosphodiesterase ; deNFP ; dephosphorylated neurofilament protein ; EM ; electron microscopy ; EtOH ; ethanol ; IR ; immunoreactivity ; LFB ; Luxol Fast Blue ; MBP ; myelin basic protein ; PBS ; phosphate-buffered saline ; PLP ; proteolipid protein ; NFP ; neurofilament protein ; NFH ; neurofilament heavy ; NFL ; neurofilament light
- 刊名：Brain Research
- 出版年：2015
- 出版时间：5 October 2015
- 年：2015
- 卷：1622
- 期：Complete
- 页码：7-21
- 全文大小：6503 K
文摘
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Withdrawal escalates myelin damage following chronic intermittent ethanol (CIE).
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Concomitant axonal degeneration is associated with CIE-induced alterations in myelin.
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CIE-induces degeneration of axons and myelin in spinal cord in addition to brain.
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Calpain activation and dysregulation of calpain-calpastatin causes axon-myelin degeneration.
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Calpain inhibition protects against CIE-induced axon-myelin degeneration.