Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort

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• 作者：Marcelo F. Lopez^a ; ^{lopezm@musc.edu} ; Michael F. Miles^d ; ^e ; ^f ; Robert W. Williams^g ; Howard C. Becker^a ; ^b ; ^c
• 关键词：Ethanol dependence ; Voluntary ethanol intake ; Recombinant inbred BXD mice
• 刊名：Alcohol
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：58
• 期：Complete
• 页码：73-82
• 全文大小：1574 K
• 卷排序：58

文摘

CIE exposure induces changes in voluntary ethanol intake that vary between C57BL/6J and DBA/2J genotypes of mice. Heritability of variation is above 50% and increases following treatment. CIE and air control, exposure induces increases or decreases in ethanol intake across BXD genotypes. The increase or decrease in intake does not depend on BEC during CIE exposure.