MHC-I promotes apoptosis of GABAergic interneurons in the spinal dorsal horn and contributes to cancer induced bone pain
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- 作者：Qiaochu Fua ; Dai Shia ; Yaqun Zhoua ; Hua Zhenga ; Hongbing Xianga ; Xuebi Tiana ; Feng Gaoa ; Anne Manyandeb ; Fei Caoc ; Yuke Tiana ; yktian@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Dawei Yed ; dy0711@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MHC-I ; Cancer induced bone pain ; GABAergic interneurons ; Disinhibition ; CD8+ T cells
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：286
- 期：Complete
- 页码：12-20
- 全文大小：2123 K
文摘
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MHC-I expression increased on GABAergic interneurons in the spinal dorsal horn of bone cancer rats.
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Increased expression of MHC-I can remove GABAergic interneurons in the spinal cord by promoting its apoptosis.
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Knockdown of MHC-I can alleviate the apoptosis of GABAergic interneurons and reversed mechanical allodynia.
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MHC-I induced the apoptosis of GABAergic interneurons is related to CD8+ T cells in the CNS.