Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder

详细信息    查看全文

• 作者：Patrick M. Brunner¹ ; Jonathan I. Silverberg² ; Emma Guttman-Yassky³ ; Amy S. Paller² ; ^{apaller@northwestern.edu} ; Kenji Kabashima⁴ ; Masayuki Amagai⁵ ; Thomas A. Luger⁶ ; Mette Deleuran⁷ ; Thomas Werfel⁸ ; Kilian Eyerich⁹ ; Georg Stingl¹⁰ ; Councilors of the International Eczema CouncilMartine Bagot ; Dirk Jan Hijnen ; Michael Ardern-Jones ; Nick Reynolds ; Phyllis Spuls ; Alain Taieb
• 关键词：AD ; atopic dermatitis ; CI ; confidence interval ; OR ; odds ratio ; Th ; T helper
• 刊名：Journal of Investigative Dermatology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：1
• 页码：18-25
• 全文大小：353 K
• 卷排序：137

文摘

Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis), suggesting both cutaneous and systemic immune activation. In reviewing atopic dermatitis comorbidities, Councilors of the International Eczema Council found a strong pattern of immune activation in peripheral blood and the propensity to both skin and systemic infections. Associations with cardiovascular, neuropsychiatric, and malignant diseases were increasingly reported, but confirmation of their link with atopic dermatitis requires longitudinal studies. Given the possibility of atopic dermatitis-related systemic immune activation, future investigations of new interventions should concurrently examine the impact on these comorbidities.