Minimally Invasive Surgical Staging for Ovarian Carcinoma: A Propensity-Matched Comparison With Traditional Open Surgery

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• 作者：Antonino Ditto ; MD^a ; Giorgio Bogani ; MD ; PhD^a ; ^{giorgio.bogani@istitutotumori.mi.it} ; Fabio Martinelli ; MD^a ; Mauro Signorelli ; MD^a ; Valentina Chiappa ; MD^a ; Cono Scaffa ; MD^a ; Alice Indini ; MD^a ; Umberto Leone Roberti Maggiore ; MD^b ; ^c ; Domenica Lorusso ; MD ; PhD^a ; Francesco Raspagliesi ; MD^a
• 关键词：Laparoscopy ; Long-term outcomes ; Open surgery ; Ovarian cancer ; Survival
• 刊名：Journal of Minimally Invasive Gynecology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：98-102
• 全文大小：447 K
• 卷排序：24

文摘

Growing evidence supports the safety of a laparoscopic approach for patients affected by apparent early-stage ovarian cancer. However, no well-designed studies comparing laparoscopic and open surgical staging are available. In the present investigation we aimed to provide a balanced long-term comparison between these 2 approaches.DesignRetrospective study (Canadian Task Force classification II-2).SettingTertiary center.PatientsData of consecutive patients affected by early-stage ovarian cancer who had laparoscopic staging were matched 1:1 with a cohort of patients undergoing open surgical staging. The matching was conducted by a propensity-score comparison.InterventionLaparoscopic and open surgical staging.Measurements and Main ResultsFifty patient pairs (100 patients: 50 undergoing laparoscopic staging vs 50 undergoing open surgical staging) were included. Demographic and baseline oncologic characteristics were balanced between groups (p > .2). We observed that patients undergoing laparoscopic staging experienced longer operative time (207.2 [71.6] minutes vs 180.7 [47.0] minutes; p = .04), lower blood loss (150 [52.7] mL vs 339.8 [225.9] mL; p < .001), and shorter length of hospital stay (4.0 [2.6] days vs 6.1 [1.6] days; p < .001) compared with patients undergoing open surgical staging. No conversion to open surgery occurred. Complication rate was similar between groups. No difference in survival outcomes were observed, after a mean (SD) follow-up of 49.5 (64) and 52.6 (31.7) months after laparoscopic and open surgical staging, respectively.ConclusionsOur findings suggest that the implementation of minimally invasive staging does not influence survival outcomes of patients affected by early-stage ovarian cancer. Laparoscopic staging improved patient outcomes, reducing length of hospital stay. Further large prospective studies are warranted.