The role of splenectomy before liver transplantation in biliary atresia patients

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• 作者：Yoshiaki Takahashi ^{yoshiaki@med.kyushu-u.ac.jp} ; Toshiharu Matsuura ; ^{matsuura@pedsurg.med.kyushu-u.ac.jp} ; Yusuke Yanagi ; Koichiro Yoshimaru ; Tomoaki Taguchi
• 关键词：Splenectomy ; Liver transplantation ; Biliary atresia
• 刊名：Journal of Pediatric Surgery
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：51
• 期：12
• 页码：2095-2098
• 全文大小：291 K
• 卷排序：51

文摘

There is currently no unified view regarding whether liver transplantation or splenectomy should be performed for hypersplenism before liver transplantation in biliary atresia (BA) patients. We herein describe the efficacy of splenectomy before liver transplantation.MethodsSplenectomy was performed in ten patients with hypersplenism associated with BA. We retrospectively reviewed their perioperative and postoperative courses, the number of leukocytes and thrombocytes, and the MELD score.ResultsThe mean age was 17.5 ± 7.0 years (range 11–31 years), and the male-to-female ratio was 1:1. The platelet and leukocyte levels increased after splenectomy and returned to normal levels one month postoperatively. The mean MELD score after splenectomy was significantly decreased after splenectomy: 10 ± 2.1 vs 7.6 ± 1.8. In particular, PT-INR improved. Five patients underwent liver transplantation because of hepatopulmonary syndrome and repeated bouts of cholangitis, whereas the remaining five patients did not undergo liver transplantation because of improvements in the liver function (the mean follow-up period was 56 months). The postoperative complications included portal vein thrombosis and intestinal perforation, but the patient survival rates remained at 100%.ConclusionAfter splenectomy, both pancytopenia and the liver function clearly improved. Splenectomy should therefore be a treatment option for patients with hypersplenism before liver transplantation.Level of EvidenceRetrospective Comparative Study – Level III.