Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1
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- 作者：Hye-Jin Leea ; Ji-Hye Yoona ; Ji-Seon Ahna ; Eun-Hye Joa ; Mi-Yeon Kima ; Young Chul Leea ; Jin Woo Kimb ; Eun-Jung Anna ; eunjung36@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hee-Sae Parka ; proteome@jnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP1 ; Activator Protein 1 ; JICD ; Jagged1 intracellular domain ; Notch1-IC ; Notch1 intracellular domain ; Neurl1 ; Neuralized-like 1
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：1853
- 期：11
- 页码：2918-2928
- 全文大小：1472 K
文摘
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Fe65 inhibits AP1-mediated JICD transactivation in a Tip60-independent manner.
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Fe65 induces the Jagged1 degradation by both proteasomal and lysosomal proteolysis.
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Fe65 interacts with Jagged1 and JICD.
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Fe65 promotes the interaction between Jagged1 and E3 ligase Neurl1.